We have a job opening for a project manager to help orchestrate efforts associated with our autism research, in particular the Autworks web portal. Please contact us if you are interested. Competitive salary, great working environment, and an opportunity to contribute to an important cause -- the search for the genetic causes of autism.
The Wall Lab's Blog at Harvard Medical School
A study published in PLoS ONE conducted CNV analysis on Autism patients [van der Zwaag et al., 2009]. While there are other similar analyses, the noteworthy points in this one are:
1) In addition to the control group, the patients are divided into two groups, complex-autism group where patients have both autism and other neurological disorders, and non-complex-autism group.
2) Significant CNVs were inferred between the non-complex and control group.
3) Among genes located in those CNVs, there is an over-representation of those involved in glycosylation.
Here is a short evaluation I wrote for f1000. It briefs a recent paper in Science titled "Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation" by Zhang et al.
Transforming "personalized genomics" from party hype into clinical action requires disruptive computational innovation that is based within the heart of the health care enterprise. That is why I recently elected to join the Department of Pathology at Beth Israel Deaconess Medical Center to help launch a new program in Genomic Pathology.
In 1967, Henry Bennet-Clark discovered that fleas store the energy needed to catapult themselves into the air in an elastic pad made of resilin. However, in the intervening years debate raged about exactly how fleas harness this explosive energy.
New research into how fleas leap.
"The insects transmit the force from the resilin spring in the thorax through leg segments acting as levers to push down on the tarsus and launch the 0.7 mg animals at speeds as high as 1.9 m s–1."