As global temperatures and energy costs continue to soar, renewable sources of energy will be key to a sustainable future. An attractive replacement for gasoline is biofuel, and in two studies published online in Genome Research (www.genome.org), scientists have analyzed the genome structures of bioethanol-producing microorganisms, uncovering genetic clues that will be critical in developing new technologies needed to implement production on a global scale.
A University of Colorado at Boulder team has developed the first atlas of bacterial diversity across the human body, charting wide variations in microbe populations that live in different regions of the human body and which aid us in physiological functions that contribute to our health.
An international team of researchers has decoded the genome of the domestic horse Equus caballus, revealing a genome structure with remarkable similarities to humans and more than one million genetic differences across a variety of horse breeds. In addition to shedding light on a key part of the mammalian branch of the evolutionary tree, the work also provides a critical starting point for mapping disease genes in horses.
Breaking up may actually not be hard to do, say scientists who've found a population of tropical butterflies that may be on its way to a split into two distinct species.
When it comes to plants' innate immunity, like many of the dances of life, it takes two to tango. A receptor molecule in the plant pairs up with a specific molecule on the invading bacteria and, presto, the immune system swings into action to defend against the invasion of the disease-causing microbe.
Female water striders often reject their most persistent and aggressive suitors and prefer the males who aren't so grabby, according to new research. Water striders are insects commonly seen skittering across the surface of streams.
A gene associated with longevity in roundworms and humans has been shown to affect the function of stem cells that generate new neurons in the adult brain, according to researchers at the Stanford University School of Medicine. The study in mice suggests that the gene may play an important role in maintaining cognitive function during aging.
A new study by a team of researchers led by Crislyn D'Souza-Schorey, associate professor of biological sciences at the University of Notre Dame, sheds light on the molecular basis by which tumor cells modulate their surroundings to favor cancer progression.
Embryonic development is like a well-organised building project, with the embryo's DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes. These patterns of gene expression are controlled by transcription factors: molecules which bind to stretches of DNA called cis-regulatory modules (CRMs), and, once bound, switch the relevant genes on or off. Thanks to scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, it is now possible to accurately predict when and where different CRMs will be active. The study, published today in Nature, is a first step towards forecasting the expression of all genes in a given organism and demonstrates that the genetic regulation that is crucial for correct embryonic development is more flexible than previously thought.
The same genes that are chemically altered during normal cell differentiation, as well as when normal cells become cancer cells, are also changed in stem cells that scientists derive from adult cells, according to new research from Johns Hopkins and Harvard.
Scientists in Belgium have successfully differentiated human embryonic stem cells (hESC) into major cell types of lung epithelial tissue using a convenient air-liquid interface. The technique, published in BioMed Central's open access journal Respiratory Research, could provide an alternative to lung transplants for patients with lung injury due to chronic pulmonary disease and inherited genetic diseases such as cystic fibrosis.
The transition zone can be one of the most challenging places to maintain high-quality turfgrass; changeable growing conditions in these regions often prove too hot for some grasses and too cold for others. Finding turfgrass that thrives in these challenging environments can be perplexing for turf management professionals and homeowners alike.
Research scientists at Nova Scotia Agricultural College have been working steadily to find effective organic methods to control weeds in cultivated blueberry crops. One resulting study, published in a recent issue of the ASHS journal HortScience, reported on the efficacy of three organic mulches used on highbush blueberry (HBB) produced under organic production practices. The research team determined that the major factor influencing weed suppression by compost mulches (for certain weed species) was likely mulch thickness and bulk density, which provide a barrier to weed growth and prevents light penetration to the soil surface.
A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants. This is the finding of a research collaboration involving Adrian Krainer, Ph.D., of Cold Spring Harbor Laboratory (CSHL) and scientists from Paratek Pharmaceuticals and Rosalind Franklin University of Medicine and Science.
An international group of scientists is proposing to generate whole genome sequences for 10,000 vertebrate species using technology so new it hasn't yet been invented. But the scientists say new genome sequencing protocols that will allow them to embark on the project are close to completion and may be available within a year or two.
The Singapore laboratory that deciphered the DNA codes, or genomes, of the famed fugu (or pufferfish) and elephant shark, has joined The Genome 10K Project, an international effort to build an invaluable repository of DNA sequences on 10,000 species of animals for conducting comparative studies on a scale that currently can not be achieved.
Colonies of army ants, whose long columns and marauding habits are the stuff of natural-history legend, are usually antagonistic to each other, attacking soldiers from rival colonies in border disputes that keep the colonies separate. But new work by a researcher at the Harvard Museum of Comparative Zoology and colleagues at the University of Copenhagen shows that in some cases the colonies can be cooperative instead of combative.
Designers of anti-cancer drugs are aiming their arrows at mysterious chunks of the genetic material DNA that may play a key role in preventing the growth and spread of cancer cells, according to an article in the current issue of Chemical & Engineering News, ACS' weekly newsmagazine.
Our lab is interested in computational approaches to understanding biological function and the genetic basis of diseases. Our work falls into three interrelated aims.
