Scientists in Michigan are reporting the development of a powerful new probe for identifying proteins affected by a key chemical process important in aging and disease. The probe works like a GPS or navigation system for finding these proteins in cells. It could lead to new insights into disease processes and identify new targets for disease treatments, the researchers say. Their study is scheduled for the Sept. 18 issue of ACS Chemical Biology, a monthly journal.
Genes that regulate the energy consumption of cells have a different structure and expression in type II diabetics than they do in healthy people, according to a new study from the Swedish medical university Karolinska Institutet published in Cell Metabolism. The researchers believe that these 'epigenetic mutations' might have a key part to play in the development of the disease.
As much as half of California could be occupied by new bird communities by 2070 according to a new study by PRBO Conservation Science (PRBO) and partners. The publication entitled "Reshuffling of species with climate disruption: A no-analog future for California birds?" is to be released in the open access peer reviewed journal PLoS ONE on September 2nd.
One way in which men and women differ is in their expression of liver proteins that control a large number of whole-body processes such as energy generation and lipid and steroid hormone production and turnover. Now, Walter Wahli and colleagues, at the University of Lausanne, Switzerland, have identified a new mechanism underlying this differential expression of proteins in male and female mice.
Humans and chimpanzees are genetically very similar, yet it is not difficult to identify the many ways in which we are clearly distinct from chimps. In a study published online in Genome Research (www.genome.org), scientists have made a crucial discovery of genes that have evolved in humans after branching off from other primates, opening new possibilities for understanding what makes us uniquely human.
In the open ocean, species of large predatory fish will swim and hunt for food at various depths, which leads to unique diets in these fish. Oceanographers and geologists in the School of Ocean and Earth Science and Technology (SOEST) at the University of Hawaiʻi at Mānoa (UHM) and colleagues have found that those fish that hunt deeper in the open ocean have higher mercury concentrations than those that feed near the surface of the ocean because their deep water food has higher mercury. This research was detailed in the August 18th early edition of the prestigous journal the Proceedings of the National Academy of Sciences.
Veterinarians from the Wildlife Conservation Society's Bronx Zoo and the University of Tennessee have found a solution to the challenge of providing effective pain relief to some of their most difficult patients: big cats.
Like most invasive plants introduced to the U.S. from Europe and other places, garlic mustard first found it easy to dominate the natives. A new study indicates that eventually, however, its primary weapon – a fungus-killing toxin injected into the soil – becomes less potent.
University of Michigan scientists say they have uncovered a fundamentally new mechanism that holds in check aggressive immune cells that can attack the body's own cells. The findings open a new avenue of research for future therapies for conditions ranging from autoimmune diseases to organ transplants to cancer.
A study in the September issue of Cell Metabolism, a Cell Press publication, may give new meaning to the adage, "You are what you eat."
A process that limits the number of times a cell divides works much differently than had been thought, opening the door to potential new anticancer therapies, researchers at UT Southwestern Medical Center report in the Aug. 7 issue of the journal Cell.
Gene therapy holds promise in the treatment of a myriad of diseases, including cancer, heart disease and diabetes, among many others. However, developing a scalable system for delivering genes to cells both efficiently and safely has been challenging.
A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. Since this RNA also facilitates the formation of DNA at telomeres—a process that can protect aging cells and destabilize tumor cells—manipulating its expression may be useful in treating cancer and other diseases.
Researchers have completed the first thorough, system-level assessment of the diversity of an environmentally important genus of microbes known as Shewanella. Microbes belonging to that genus frequently participate in bioremediation by confining and cleaning up contaminated areas in the environment.
Drawing on the power of DNA sequencing, National Institutes of Health researchers have identified a new group of genetic mutations involved in the deadliest form of skin cancer, melanoma. This discovery is particularly encouraging because some of the mutations, which were found in nearly one-fifth of melanoma cases, reside in a gene already targeted by a drug approved for certain types of breast cancer.
The drywood termite, Cryptotermes secundus, eavesdrops on its more aggressive subterranean competitor, Coptotermes acinaciformis, to avoid contact with it, according to scientists from CSIRO Entomology and the University of New South Wales at the Australian Defence Force Academy.
A research report featured on the cover of the September 2009 print issue of The FASEB Journal (http://www.fasebj.org) describes how Australian scientists developed a new gene therapy vector that uses the same machinery that viruses use to transport their cargo into our cells. As a result of this achievement, therapeutic DNA can be transferred to a cell's nucleus far more efficiently than in the past, raising hopes for more effective treatment of genetic disorders and some types of cancers.
Travelers to the neotropics—the tropical lands of the Americas—might be forgiven for thinking that all of the colorful insects flittering over sunny puddles or among dense forest understory are butterflies. In fact, many are not. Some are moths that have reinvented themselves as butterflies, converging on the daytime niche typically dominated by their less hairy relatives. Now, a new revision of the taxonomic relationships among one such group of insects, the subfamily Dioptinae, sheds light on the diversity of tropical moth species and presents a unique story of parallel evolution.
Fast growing transgenic fish can revolutionise commercial fish farming and relieve the pressure on overexploited fish stocks. But what happens in the natural environment if transgenic fish escape? Researchers at the University of Gothenburg have studied transgenic fish on behalf of the EU and are urging caution: -Until further notice transgenic fish should be bred in closed systems on land, says Fredrik Sundström at the Department of Zoology, University of Gothenburg.
Viruses have numerous tricks for dodging the immune system. In the September 7, 2009 issue of the Journal of Cell Biology, Stagg et al. reveal a key detail in one of these stratagems, identifying a protein that enables cyto¬megalovirus to shut down an antiviral defense (online August 31).
Our lab is interested in computational approaches to understanding biological function and the genetic basis of diseases. Our work falls into three interrelated aims.
