New findings from an international team of researchers probing the nerve-insulating myelin sheath were bolstered by the work of Boston College biologists, who used x-rays to uncover how mutations affect the structure of myelin, a focal point of research in multiple sclerosis and other neurological disorders.
The atomic-level action of a remarkable class of ring-shaped protein motors has been uncovered by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) using a state-of-the-art protein crystallography beamline at the Advanced Light Source (ALS). These protein motors play pivotal roles in gene expression and replication, and are vital to the survival of all biological cells, as well as infectious agents, such as the human papillomavirus, which has been linked to cervical cancer.
Scientists have crystallised a protein that may help gut bacteria bind to the gastrointestinal tract. The protein could be used by probiotic producers to identify strains that are likely to be of real benefit to people.
The Wildlife Conservation Society (WCS) announced today a report revealing that the last remaining population of Siberian tigers has likely declined significantly due to the rising tide of poaching and habitat loss.
Rocket science is opening new doors to understanding how sounds associated with Navy sonar might affect the hearing of a marine mammal – or if they hear it at all.
Universitat Autònoma de Barcelona (UAB) researchers have confirmed that a diet rich in polyphenols and polyunsaturated fatty acids, patented as an LMN diet, helps boost the production of the brain's stem cells -neurogenesis- and strengthens their differentiation in different types of neuron cells. The research revealed that mice fed an LMN diet, when compared to those fed a control diet, have more cell proliferation in the two areas of the brain where neurogenesis is produced, the olfactory bulb and the hippocampus, both of which are greatly damaged in patients with Alzheimer's disease. These results give support to the hypothesis that a diet made up of foods rich in these antioxidant substances could delay the onset of this disease or even slow down its evolution.
A new study by the Wildlife Conservation Society says that western lowland gorillas living in a large swamp in the Republic of Congo—part of the "mother lode" of more than 125,000 gorillas discovered last year—are becoming increasingly threatened by growing humans activity in the region.
Since 1996, crop plants genetically modified to produce bacterial proteins that are toxic to certain insects, yet safe for people, have been planted on more than 200 million hectares worldwide. The popularity of these Bt crops, named after the bacterium Bacillus thuringiensis, comes from their ability to kill some major pests, allowing farmers to save money and lessen environmental impacts by reducing insecticide sprays.
A novel approach to classify the gender of six-week-old turkey poults could save millions of male chicks from being killed shortly after birth, according to Dr. Gerald Steiner from the Dresden University of Technology in Germany and his team. Their use of infrared spectroscopy to determine the gender of young birds shows that it is a fast and accurate method with the potential to be used by the breeding industry to identify and select female eggs for breeding. The pilot study¹ has just been published online in Springer's journal Analytical and Bioanalytical Chemistry.
The generation of new nerve cells in the brain is regulated by a peptide known as C3a, which directly affects the stem cells' maturation into nerve cells and is also important for the migration of new nerve cells through the brain tissue, reveals new research from the Sahlgrenska Academy published in the journal Stem Cells.
The time of day matters to forest trees dealing with drought, according to a new paper produced by a research team led by Professor Malcolm Campbell, University of Toronto Scarborough's vice-principal for research and colleagues in the department of cell and systems biology at the St. George campus.
A new species of chameleon has been discovered in Tanzania by a team of scientists.
Amphibians like frogs and toads have existed for 360 million years and survived when the dinosaurs didn't, but a new aquatic fungus is threatening to make many of them extinct, according to an article in the November issue of Microbiology Today.
For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought.
In a research report published in the November 2009 issue of the journal GENETICS (http://www.genetics.org), scientists show how a family of genes (1-aminocyclopropane-1-carboxylate synthase, or ACS genes) are responsible for production of ethylene. This gas affects many aspects of plant development, and this information lays the foundation for future genetic manipulation that could make plants disease resistant, able to survive and thrive in difficult terrain, increase yields, and other useful agronomical outcomes. This discovery was made with the weed Arabidopsis thaliana, but it will be applicable to plants used in agriculture.
A key question in the origin of biological molecules like RNA and DNA is how they first came together billions of years ago from simple precursors. Now, in a study appearing in this week's JBC, researchers in Italy have reconstructed one of the earliest evolutionary steps yet: generating long chains of RNA from individual subunits using nothing but warm water.
Bacteria possess an ingenious mechanism for preventing oxygen from harming the building blocks of the cell. This is the new finding of a team of biologists that includes Joris Messens of VIB, a life sciences research institute in Flanders, Belgium, connected to the Vrije Universiteit Brussel. The scientists made this discovery by modifying the DNA of the intestinal bacterium Escherichia coli. By means of this model organism, they have uncovered the existence of a mechanism that repairs proteins in the cell that have been damaged by oxygen. There are indications that a similar repair system is active in human cells. The research results are being published in the eminent scientific journal Science. At the same time, the researchers are posting an animation online that illustrates the finding.
Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on infection control and immune disorders. The discovery is such a crucial part of immunology that UAB researchers, in conjunction with Japanese researchers, are asking that the gene linked to this antibody receptor be renamed to better describe its role in early immune responses.
A new treatment route for bovine spongiform encephalopathy (BSE) and its human form Creutzfeldt Jakob disease (CJD) could be a step closer based on new results from scientists at the University of Leeds. The team has found that a protein called Glypican-1 plays a key role in the development of BSE. Details are published November 20 in the open-access journal PLoS Pathogens.
A mathematical model has explained some of the remarkable features of mosquito hearing. In particular, the male can hear the faintest beats of the female's wings and yet is not deafened by loud noises.
Our lab is interested in computational approaches to understanding biological function and the genetic basis of diseases. Our work falls into three interrelated aims.